Evaluation of Human Resources Essay

Businesses have to control their resources closely, this is because Human resources are needed in the business and is also monitored because if some staff are not doing their work correctly then they are likely to be replaced with someone that is better. If the business is to expand then the business needs to employ staff with certain ability that will benefit their business. The Human resources can improve the businesses performance in many ways. There are two main processes which are looked at when managing human resources. The most important is to employ the correct people for the job, people that will carry out the job role correctly. Then the correct resources have to be provided for them so that they can carry this process out to the best of their standards. Treating these employees with care and sensitivity is important. They are not like physical or technological resources; humans need to be dealt in certain ways, as they are protected by legislations and laws. In some businesses, there will be a constant change of different demand of products that the customers wish to purchase, for this reason the staff will have to be trained for any of these occasions. This is how they improve there human resources. They also look at how many skills the employee has when they are searching for new employees. They will check whether that person can be used in more then one job position of that store, how many skills they consist of. Coordination of the teams in different types of businesses is very important in ensuring that they meet the targets that the company sets them. When all employees of the team complete their assigned roles the team will run more smoothly. It is also important that a manager is always there so that they can supervise his staff and also if there is a problem that they might not be able to handle the manager will defiantly being trained to deal with the situation. Monitoring the performance of a team and letting them know of there good work is a good way to keep the staff motivated. There are certain ways to monitor the way that businesses monitor their staff. Firstly they can make sure that the staffs are reaching the targets that are assigned to them. Also sales figures can be looked at, seeing whether the team has overspent or under spent the budget that was assigned to them. Finally last way to monitor the performance is to record the number of compliments, or complaints that that member of staff has received from the customers. Individual and team appraisals are also a good way to keep the team motivated. Liaising within departments in a business is very important in keeping the employees on talking terms with people in other departments. It is essential that they work with each other so that they can coordinate with each other and progress is completed rather then slowed down. One way to make sure that the teams work together is to encourage team building exercises, so that the employees can get to know each other more. Many people from the same level within the organisation are told to meet with other people from other departments, not necessarily physically, but through the internet. To ensure that the employees know how the business works, and what there job role entitles, they should know about the background of their organisation. There will have to be good communication and respect shown when the people of the company are talking to each other. People will talk to others in a different way depending on there role, or what they have achieved. With there superiors there will be more respect shown then others like people below them in the organisation. In some businesses managers will refer to each other using there titles but many others, they will be referred to on first name bases. It is also important to communicate with the employees, make sure that they know the terms of there contract with the job that they have with you, whether they are allowed to have a second job or not, these little things. If they choose to have a second job, they should tell their role manager about it, and also the job should be in a non-related company. Managers can use incentives to keep the workforce encouraged to work harder and harder. There are many ways in which employees can use these incentives to keep them working, they can be rewards, little things that will make the workforce feel that that are being appreciated. These incentives also have to be worth of value to the employee that is earning them, or they will not want to earn them. It is always good to offer a variety of choices for the employees to choose from. This way they can have different things every time that they work hard. Businesses usually encourage there employees to be creative, and use their initiative. This is to adapt with any change in the market, so that the company is easily adaptable, and these companies are more likely to succeed. Because companies can compete all over the world using the internet, these companies’ encourage their employees to think creatively and use their imagination. Many small businesses become successful by being creative and using their initiative. Organisations can get their work done in two different ways, one in-house, where the employees that they employee do the work for them, or the organisation can outsource their work, where they pay some other company to do the work for them. Evaluation of Technological Resources: When looking at resources which are technological, there are many improvements that can be made in a business. Technological resources would not be hardware; they would fall under the category of software. They are managed in similar ways to other resources to ensure that they are not damaged, and if there is a newer version an update can be made. Intellectual property is the right in which people can own idea’s and decide what happens to them. This is similar to having a patent to an idea or an item, where the person will decide what will happen to the item or ideas. The longer that people work in a job, or different jobs they will start to gain accumulated experience, they will start to learn how to deal with certain issues that may come up in their job. This is a major benefit to the company, as more and more people stay at the company, gradually gaining more experience. The people with experience will be placed as mangers so that they can have an influence on their own sector or department. It is very important for the organisation to build up the skills of peoples so that they can deal with certain issues that arise in the business. It would be wise to train more then a few people at certain things, for instance in their absence, there should be somebody to handle that specific area. If an experienced person was to leave the organisation it would be hard to find another person that would be able to fulfil that job role with the same amount of skill as the previous person. Cascading training is the process in which training is passed on throughout the workforce, so that a backup is available when another individual is needed. Software is used in businesses a lot, and the businesses spend a lot of money on software for its business. Specially made software is sometimes very important to businesses; the reason for this is because it is a piece of software that is specifically designed for a business. Software that isn’t specially made, but owned by people is also used, and to use these businesses must pay a fee for the software license so that they can distribute it to all of their stores. When companies buy these licenses, they usually get a discount due to the amount of computers that they wish to install the software onto. Some companies run the software on more computers they claim to be, and in these cases they are breaking the law, although this can work both ways, as the companies can charge too much. Software reviews can save a vast amount of money for the company, to see which computers need new software and which don’t. Using legislation to protect the technological resources of the company is very important although it is always hard to tell whether people have taken your idea, it is always hard to find the perpetrators. Patents and Copyrights are different area’s which fall under intellectual property law. Patents are protection for inventions, new or improved. Evaluation of Physical Resources: When looking at the physical resources of business, businesses should look at the procedures that it undertakes to carry out its activities. Improvements can be made to make sure that these resources are maintained, refurbished and secured. All businesses need premises where they can operate from. These buildings can have a strong affect on the people that either work there, or the customers of the company. Having buildings located in strong economic areas is also very important for the business, so that many people will be attracted to it, as well as see it as an important building in the area. Importance of how businesses layout their stores all over the country, no doubts show in its success. Businesses have to find ways into attracting the attention of the customers. In businesses that deal with clothing, shoes or accessories, they would need to be aesthetically pleasing to the customers, being attracted to the building will naturally result in them proceeding into the building. Improvements should be made in the materials and waste in businesses. Undoubtedly this would both save the economy as well as money for the business. Different types of buildings within each business will all need to cope with different activities that will need to be completed. The plant will be the place where the machinery for these places will be placed. Although some companies take there machinery on lease, some businesses see it as best to buy the machinery as they can be used in the long run. The correct equipment is essential for a business to operate smoothly. If the necessary equipment is not given then this can result in the incompletion of the task which was required, this can have more impact on the company then some may think. IT is one of the most important, many businesses fail without it. Businesses must consist of both hardware and software, which carry out their main jobs of looking after the amount of stock in the stores, the day’s cash intake, and many other important functions that the company needs. Hardware is the physical items, computers, monitors, things that are visible to people. Software would be the systems that the computer runs on, Microsoft and other applications. All of the factories will always have their premises checked. If the correct maintenance does not take place then the machinery or the buildings can break down, leading to much more large cost with replacing them. Cleaning of the buildings is important in keeping it safe to work in and healthy for the people who work there. Refurbishment of the company consists when the company seems to want to change the appearance of their stores whether it is to the customers in the stores, or for the workers in the other associated buildings. Keeping the buildings fresh will encourage people to enjoy their workplace and result in people working harder. Refurbishment can also have an impact on the environment as well as people, as old resources can be replaced with eco-friendly or energy saving ones. To ensure that the workers and the customers are safe at all times Emergency Provisions will be there in case of an emergency. Evacuation training must be given to all of the employees, so that they know exactly what to do in case of a fire or any other incidence. Other equipment to prevent harm will be placed in the store, such as, fire alarms, smoke detectors, fire escapes and fire extinguishers. To ensure that these are working at all times, regular checks will need to be made. Insurance is a must with all building, whether there leased or owned by the company. This is to cover any damages. Protecting the assets of the company is very important because if any of these were vandalised, they can claim the damage costs back. The building must be made secured at all times, when the employees finish their shift at night; they must lock the premises up so that no intruder can enter. Although this is not always the case, people still somehow find a way in, this is why security guards are hired. The company can also get advice from big security companies about how they can keep their business locked and secure. Evaluation of Financial Resources: Financial resources are needed in the businesses because they have to monitor their finance because; they need to insure that they have enough money in order to buy products and to pay their employees. They then also have to make sure that they have enough money so that they can pay off their bills as well. Financial resources are the cash or loans that a business has, or has access to. A business’s non-financial resources are their employees, technology, equipment, buildings, warehouses and information systems. Within the financial and non-financial category come two more types of resources: internal and external. Internal resources are financial or non-financial resources that a company owns, or has in-house. External resources are financial or non-financial resources that a company does not own, but may be able to use externally. When businesses evaluate their internal environment, they are analysing the areas of their work that they have control over. Internal environments may include, but are not limited to, the organisational structure, purchasing behaviours, research and development and manufacturing processes. Within the internal environment are internal resources, such as finances, staff, equipment, and machinery and information technology. Businesses should perform environmental scans of their internal environments and resources, they should document their findings, examine the trends in their environment, review and analyse the inventory and use the information for decision-making techniques. External business environments are the areas that a business does not have control over, but can still be impacted by. Common external environments can be categorised as environmental, political, economical, technological, legal and social. Within these external environments businesses can identify external resources. Technological advances, for instance, are operated external resources. By knowing what is available to businesses in the external environment, decision makers can analyse risk potential and understand how their business can be progressed or slowed down by external resources. Monitoring Budget Costs: At the beginning of a businesses year, the business will start to start formulate a budget which is their objective to forecast what their profit will be at the end of the year in the assumption that the budget will remain the same through out. The budget will be monitored quarterly or monthly to see if the profit they projected at the beginning of the year is still realistic. Monitoring their budget will give them the flexibility to adjust their wants, needs and must have so that the projected profit is realisable at the end of the year. Profit is the measure of a business performance. Ideally, the process of budget planning for the next financial year should give everyone in the organisation an opportunity to reflect on what they’ve achieved, what the external environment is telling them and where they want to go next. In times of recession, businesses will aim to increase revenues or they may maintain them, they could specifically target a certain market, or invest more in a profitable area. Businesses will focus on these specific areas by everyone in the business. Unfortunately, hardly any business gathers the full rewards of focused engagement with the budget process. Too often businesses are facing the future with budgets that are reluctantly thrown together by cost centre managers with other things on their mind.

Management Essay

Essay Title: Suggest ways in which managers can choose to manage diversity in the workplace. Illustrate with examples from organisational practice. Gilmore, Williams et al, 2009. Human Resource Management. New York: Oxford University. Summary This book not only describes the knowledge of human resource management (HRM) but also illustrates numerous interesting examples with further discussion, such as discussion questions and case study that link the theories and practices. In chapter 11, it mainly discusses the equality, diversity, and dignity at work with real cases, it also provides the background of diversity and the main pieces of UK equality laws. Authority The book was written by Sarah Gilmore and Steve Williams. They are two principal lecturers at the University of Portsmouth in the UK. Dr. Gilmore’s research interests are HRM, training and development and psychoanalysis. In addition, Dr. Williams co-authored Human Resource Management and other three books. For instance, Contemporary Employment Relations: a Critical Introduction (Oxford University Press, 2nd edition, 2010). Two authors both have academic background and relate in those fields. Currency The book was published in 2009. It is current enough for my research. Accuracy This book includes abundant references, it not only states the knowledge of theoretical side but also provides practical aspects such as the real case of Tesco. On the other hand, this book have many information related the Internet sources that would be lower reliable than other information. Readership Managers would read it because it would help readers to improve the knowledge about this field. Relevance The information about the UK equality law is vital important for my research. It completed my whole picture of essay. Due to, in my research the legislation is a main element to reduce the discriminations in the workplace.

Happy Life – Essay

What Is a successful life? Is it a life without concern about money, without caring about interpersonal legislations, or without suffering any discomforts? To me, if it were a life without caring about others, people would not feel happiness. If it were a life of just working hard, people would lose their family. If it were a life of being selfish all the time, people would not feel the taste of love. Therefore, In order to have a happy life, we need to control our willpower, have a good relationship with others and then live with any pains.Will power plays a very important role in one's life. When we were born, everything looks interesting to us. Or in some other cases, we are looking for troubles that we are not intended to. That is why kids need to be educated. Facts such as failing to control one's Impulses, low frustration tolerance, and failing to plan ahead always happen for a young kid. That Is why young children need constant supervision from our parents or teachers. In thes e cases, most of the will power Is established In one's childhood.As an example from the reading, † Don't, the secret of self-control†, Joana Lealer explain well why our young generation needs a good self-control to be successful in our life. His article summarizes research on self-control in children and how this factor will predict success later in their life. In his articles, researchers showed four-year-old kids a marshmallow, and told them that they â€Å"could eat one marshmallow right away, or If they were willing to wait while he stepped out for a few minutes, they could have two marshmallow when he returned. (Lealer 2009) some kids ate one marshmallow very soon, while 30% were able to wait until the researcher returned 15 minutes later-?a very long time in the life of four-year-old. Interestingly, the researchers also followed up these kid twenty years later, they found that the kids who could delay 15 minutes had an average S. A. T score that was 210 points ra ter that those who delay 30 seconds or less. (Lealer 2009) To their credit, those kids who could delay longer had fewer behavioral problems, dealt with stressful situations and maintain friendship better.I am not saying those well behave kids would be successful in the future, but at least they can control their will power, which will help them build their life better. As I was in my high school year, I met some friends who are extremely out of self-control. In their cases, they prefer having troubles with teachers and school disciplines rather than studying. They didn't come to school on time, and do the homework by themselves. I think they are In a bad they told me they feel so regret at their high school years. From them I know some of their fellows went to Jail after.That is the reason why we need a good self-control, no one want to spend the rest of his or her life in Jail. Besides having a strong will power, we also need to communicate well with others. The scale of being succ essful or happy is not measured by how much cash is in your pocket, but the relationships with others. More precisely, a good mental health really matters in one's life. In the article, â€Å"What makes us happy', Joshua Wolf Sheen argues the how interpersonal allegations effects one's life. Sheen s article is based on the Grant Study.The grant study was longitudinal research by subjects had been followed for about 70 years. The subjects were all Harvard male student from the classes of 1942, 43 and 44. The main researcher of this study, George Villain, thought, â€Å"the only things that really matters in life are your relationships to other people†. (Cheekiness) Villain regards the relationship to other people as the most important factor of people's life. It is very important to maintain close interpersonal relationships not only with our family, but also with our friends and other people.Sandra Bullock, for an example, explains us well why we need to maintain good interp ersonal relationships. In the article, † The Sandra Bullock Trade†, David Brooks persuade his audiences that, † marital happiness or interpersonal relationships is more than an accomplishment in a profession. † (Brooks 2010) In the article, Brooks discusses two things that happened to Sandra Bullock in one month, she found out that her husband was cheating on her and she won an Academy Award. Although as a normal person, we don't have a clue how Bullock feels, we know that Bullock doesn't have a happy family.Although Bullock is so successful in her career, she has no support from his family. In my opinion, I think she put too much effort into her career and she loses her family. Once one's family is not on their back, their success will not count. Besides having a good self-control and interpersonal relationship, we also need to face our pains. The more difficulties we have met, the more experiences we will have for life, and the more successful we will be in our life. From Sheens article, † What makes us Happy', he illustrates how pains related to one's happy life.I really like his mint about interpersonal relations. However, I disagree with what you said about â€Å"your feeling of how happy your life was depended on how you think, not on how many difficulties you had met. † (Sheen 2007) In my opinions, life is based on how many difficulties you have met. Because the more pains you suffered, the more experienced you will be, and the easier we will learn how to deal with them. In my family, my dad always gives me advice upon any difficulty I have met. Because he suffered those pains before, and he Just doesn't want to come through with them again.But there must be one day he can't advice me any more, because my dad and I are in a different mode of life. Thus, I need to be fully experienced to build my family. With good self-control, maintaining good interpersonal relation, and living with any pains are the ways to build a successful life. Different people suffer different lives. From the time we were born, we will face the questionnaire upon how our life will be. No one can answer this question, no one will know how one's life will be, and no one can conclude whether the life is successful or not. We start, and we should

Taxation Essay Example | Topics and Well Written Essays - 1500 words - 5

Taxation - Essay Example A good example is the when the tax revenue collected is allocated towards paying for government services such as the police, the military and the government administration. Taxes are also collected for purposes of subsidizing the needs of its citizens such as the subsidization of a staple food or education. Taxation carries the weight of bearing the load of administration as well as providing its citizens a chance to run their country. As taxpayers many people are given the opportunity over voting rights as well as social security and welfare in times of hardship. Consumption Tax: It is a system whose tax base is consumption. This includes the goods bought by an individual. The most common is the VAT (Value Added Tax) and is added already on all legal goods that are being purchased. Excises: Excise does not depend on the quality of the object rather, based on quantity amount of tax payable is calculated. It modifies the consumption pattern of user. If excise in alcohol is made higher then, rate of alcohol consumption will definitely come down. Income Tax: Tax imposed on financial income of the person is known as income tax. Income taxes are also inclusive of the profits of a business if the individual is self-employed. This tax is inclusive of a person’s savings in correlation to the amount of money that has been saved. Poll Tax: Poll tax is the fixed amount of tax that is levied to each and every individual irrespective of his/her financial strength. Though they are cheap and easily manageable but, it has one basic drawback: Poorer people need to pay higher proportion than rich persons. Property Tax: Individuals who own property are required to pay a certain amount of tax. Inheritance taxes, Stamp Duties and a tax on gifts that you have made seven years before an individuals’ death. This tax is also inclusive of all the properties a UK citizen has overseas whether or not money is brought into the

Compare and Contrast 2 Quality Management Theories Research Paper

Compare and Contrast 2 Quality Management Theories - Research Paper Example The basic contention behind the implementation of either Six Sigma or lean techniques is to increase the output from existing processes and methods. It must be taken to note that Six Sigma applies more to bolstering output by removing causes behind defects through the implementation of measurement and statistical techniques (Tennant, 2001). On the other hand, lean techniques consist largely of methods that are aimed at improving processes by looking at existing loopholes and reacting accordingly (Taylor, 2008). Need for Lean Techniques and Six Sigma in the Healthcare Sector Lean techniques are not based in large part on quantification unlike Six Sigma that dwells on quantifying defects for their removal and noting process improvement levels. In recent years, both Six Sigma and lean techniques have been used increasingly in the healthcare sector to deal with existing and emerging challenges. The increasing cost of healthcare and visits to doctors have meant that it is required to opti mize healthcare access costs through the application of Six Sigma and lean techniques. However, it must also be kept in mind that healthcare applications involve critical assessments that might end up with permanent damage to the patient’s health or might even result in a fatality (DelliFraine, Langabeer, & Nembhard, 2010). In such a case, the advantage of applying either Six Sigma or lean techniques is removed altogether as the customer is effectively permanently damaged or removed from the service list. On another note, it must be considered that the failure of Six Sigma or lean techniques in the manufacturing, services or other sectors may result in nothing more than another defect not involving loss to human beings. However, in the case of the healthcare industry, any failure of the Six Sigma or lean techniques regime could possibly lead to a human fatality which is not desirable. Therefore, the application of either Six Sigma or lean techniques requires differentiation b etween critical and non-critical applications in the healthcare sector. Requirements of Quality Management Philosophy in the Healthcare Sector The healthcare industry effectively requires a technique that is not harmful to the customers. In case that Six Sigma is applied to the healthcare industry, it would involve taking measurements as a vital method of producing baselines and quantifying output levels to see how processes have improved. As far as the manufacturing sector is concerned, Six Sigma is effective because the same manufacturing processes are being repeated to manufacture the end product. The continuous nature of the measurement ensures that Six Sigma can be applied across the board to the entire organization. Even if the services industry is considered, it becomes clear that similar end services are being provided to customers resulting in insightful measurements for Six Sigma improvements. However, the case of the healthcare sector is altogether different since any hea lthcare organization is servicing customers with multiple differentiated needs at the same time. For example, the same hospital could be dealing with emergency trauma patients as well as with cardiovascular disease patients. The wide range of processes required to satisfy the end customer do not favor Six Sigma for measurement in the healthcare sector (Taner & Sezen, 2007). Six Sigma In the case of the

Football or Tennis Essay Example | Topics and Well Written Essays - 500 words

Football or Tennis - Essay Example Tennis, on the other hand, has its own magical aura and unique charm, but in my opinion, when compared to football, it almost fails to bag the first position when it comes to the popularity of sports. This might be due to the fact that because of involvement of many players, naturally huge interest develops compared to the simplicity related to only two players involved in tennis. The comparison between the two games can be discussed in terms of the state of mind. Decisions have to be made in tennis that does not spare much time for the players. No one can disagree that all those trickiest decisions have to be made in a fraction of second and all this strategy involved in this highly fiddly game require the extraordinary presence of mind. An acute decision at the correct moments is what professional tennis is all about. The point is, all the crucial decisions have to be made single-handedly, that is in huge contrast to football, where teamwork is included and prostrating pressure doe s not have to be faced by only one person. Furthermore, tennis is primarily a one-man show whereas football requires teamwork. Also, the former is played with hands while the latter is played with feet. Summing up, hopefully, this much becomes clear from the above discussion that both games have their huge share in the entertainment world, but it would be unfair to underestimate any one of them. Deficiencies are always there but what matters is how long any game stays in vogue and both games have more or less managed to achieve this position.

Long-Term Care Essay Example | Topics and Well Written Essays - 1500 words

Long-Term Care - Essay Example The aging of America has helped to bring the issue of the state of long-term care system in the limelight. It was in 1988 when Presidential candidates talked in their debates for the elections while Congress first tried decisively to cobble a national policy on long-term care by introducing four major bills on long-term care financing (Kuchler 1). However, while America is aging, life expectancy has also lengthened so that more and more older people are joining the ranks of senior citizens - consequently, expanding the ranks of those who will face disability in the near future. In the past, the policy was geared towards institutional care, mostly nursing homes and residential care facilities, but now efforts are being done towards more a home-based or community-based care due to the wishes of the families of patients. Another socio-cultural force that has brought the long-term care system to its current state is the role played by informal caregivers, especially women. Women and relatives of the elderly and the disabled have traditionally been assigned the task of being the caregivers of the family. As a result of higher educational attainments, rising divorce rates, and more opportunities for women in the labor force, the long-term care system has been faced with the issue of dearth of informal caregivers. ... The shortage of care-giving professionals will continue to affect the state of the long-term care system in the future. Long-term care financing as well as delivery has been tasked as a matter of policy to Medicare and Medicaid, with the former including long-term care service only as an adjunct in case of acute illness for people with disabilities and the latter, as the institutional source of long-term care funding for very economically hard-up people. The policy has been criticized for failing to provide support for people who need long-term care service. Medicaid only could be relied on to provide long-term care when their financial resources have dried up and thus, "the system is excessively harsh" (Feder, Komisar and Niefeld 54). Partly the result of the inadequacy of the coverage of long-term care financing, most people especially from the middle classes rely on out-of-pocket expenses to pay for long-term care. It is estimated in one study that 20% of older people will spend US$25,000 from their own pockets to fund future long-term care needs (Johnson, Toohey and Wiener 2). There are continuin g policy debates on how to integrate Medicare and Medicaid and how these debates will fare in the coming years and thus shape whether the long-term care system will be up to the challenge of providing better services and financially viable options for the country. As the age group called the baby boomers or those who were born between 1946 and 1964 reach retirement age and who currently comprise more than a fourth of the American population, some have sounded alarms that this phenomenon is a healthcare crisis in the making (Achison n.p.). When this age group will become part of the population that will stop paying taxes that fund Medicare and would be

Aiding the Management of Change Research Proposal

Aiding the Management of Change - Research Proposal Example A survey conducted in 2002 (Online Executives 2006) highlighted that the main driver for change was increased competition, however, most domestic businesses have adapted to this by adopting similar processes and acquiring the necessary technology. However, in 2006, the survey was repeated and found that the main driver for change was the desire to increase efficiency. This is indicative of an environment that is becoming difficult to control and predict and has made planning and strategy on a short term basis. The need for efficiency is not confined to one industry but rather applies to all businesses, and this has resulted in a number of change management initiatives that are designed to increase efficiency, reduce costs, restructure the organization, and become more competitive and to make the business more innovative. However, by increasing efficiency, reducing costs and restructuring the organization, most businesses are directly impacting on employees as these drivers will have a negative impact on jobs. These drivers often result in redundancies and the key to a successful change management initiative will lie in an organization’s ability to handle and communicate with its employees (Chin and Benne 1968). Failure to communicate and implement change management to employees will make the initiative susceptible to failure through reduced morale from the remaining employees (Chin and Benne 1968, Scott 20,05), which in turn will affect the manner in how customers are treated, which in turn will affect the organizations' competitiveness. This implies that change management is not about changing physical attributes, but rather it is about managing the process of it, which includes people management. This paper will briefly look at the factors responsible for both successful and disastrous change management initiatives, and it will also look at how culture and commitment, leadership and downsizing can be managed for change.

Four major forms of ethnic violence Essay Example | Topics and Well Written Essays - 500 words

Four major forms of ethnic violence - Essay Example Life for them is a tool for power; some followers viewed it as meat for slaughter. Still others thought of violence as instrument, oddly, for political and competitive leveraging. Sociologist and anthropological experts classify the kinds of violence. These are symbolic violence, lynching, pogrom and massacre. Arnold (2012) defined symbolic violence as a form violence employed to properties of other cultures but no actual harm is done to persons. This is illustrated by attacks done to important properties, places, or place of worship to employ meaning that such violence is authored and directed towards a leader or a congregation of groups representing these edifices (Armold, 2012). The attack is a symbolic communication to intimidate the targeted victims, whether they are institutions, or groups. For instance, in a rage on a film allegedly made by a westerner Coptic Christian pertaining to the life of Muhammad in a film â€Å"Innocence of Muslim,† people who represented the religion of Islam gathered and flocked to embassies of United States of America bearing placards that assaulted the sensibilities of diplomats and its workers. Violence was done whe n its ambassador in Libya was gun down due to the showing of this film and by posting it in youtube, an online medium for vloggers. Lynching on the other hand is a murderous attack done by persons coming from a different ethnic demonization (Arnold, 2012). The attack can be done by hanging or any forms of inflicting physical harm. It may include beating but such kind enough to intimidate the family of the person within a community (Arnold, 2012). This kind of violence is done to send a signal or message to the community that anyone who will emulate the victim’s will be punished the same way. For instance, in the Philippines, some women secretly discussed about a Maranao woman being raped.

Article Essay Example | Topics and Well Written Essays - 500 words - 10

Article - Essay Example The article notes that Just-in case distribution helps companies to reduce the cost of keeping large stock by ensuring just in time supplies. In addition, the just-in case distribution also aids in reducing the cost of transportation since shipping of goods is on demand. The article asserts that the just-in-case plan was a response to the vulnerable just-in-time supply chains. The article notes that just-in-time management exposes companies to a greater risk of running out of merchandise in case of disruptions. Indeed, the article reckons that combining the just in case with just-in-time strategy was a means of seeking to a balance between holding the minimum inventory possible and yet never running out of stock. The just-in case just-in time distribution strategy expands and increases the network of distribution centers hence reducing the distance by moving the inventory more close to the customers. Apparently, the article shows that companies can achieve greater efficiency upon transporting its goods to the customers immediately. As such, many companies seek competitive advantage amidst stiff competition arising in market by offering excellent customer service. Multiple and strategically place distribution channels help in minimizing the time, money and distant spent in delivering merchandise to the customers. However, the article observes that retailers often avoid transporting merchandise to the last miles by directing the nearby customers to collect their merchandise from the nearby shop. From the content of the article, I feel that the Just-in-case  is an effective strategy in supply chain management. Indeed, the just-in-time management exposes companies to a greater risk of running out of merchandise in case of disruptions. I therefore relate the article with the benefits of the just-in case management that allows retailers to enjoy a lot of stability since there is efficient distribution of goods and they do not have to rely on one

Research paper Essay Example | Topics and Well Written Essays - 1000 words - 1

Research paper - Essay Example Children can steal for a variety of reasons like poverty, lack of parental guidance, and bad family culture. For a child that steals, there are certain roles and responsibilities of the parents and teachers. With mutual effort, parents and teachers can guide the child’s behavior so that they do not steal. It is important to differentiate between children and adults when punishment is being decided for the crime of stealing. â€Å"Your child is probably not evil or destined for life in prison† (familyeducation, 2012). Children need to be dealt with much more carefully and strategically because they have a lot of room for improvement. Reasons why children steal Children can steal for different reasons that may include but are not limited to poverty, lack of guidance, and culture. Poverty Poverty is the biggest cause of stealing among children. Children steal something when they do not get it granted to them by legitimate means. The legitimate means for a child are parents or the caregivers. Parents generally do try their best to provide everything for their children but sometimes they cannot because of which children are tempted to steal. Lack of guidance Many children lack parental guidance. Every day, so many babies are born to unmarried mothers in their teenage. As single parent, the mother cannot spend enough time with the child because she has to take care of her studies and work. The child remains alone most of the day. Even the grandparents cannot look after the child the way a parent does. â€Å"School-age kids usually know they're not supposed to take something without paying, but they might do so anyway because they lack enough self-control† (KidsHealth, 2012). The child attempts to steal. When nobody forbids, it becomes child’s habit. Family culture Every family has its own culture. In certain families, stealing is not discouraged because the parents themselves are thieves and criminals. They inculcate the same values in the ir children. In such cases, children adopt the habit of stealing from the parents. Miscellaneous reasons According to the Hudson Valley Parent Magazine (2012), children steal either to address a need like lack of attention, affection, or love from parents or because they have gained approval for stealing directly or indirectly or the children want to attack the parents by causing them embarrassment with their behavior. Guiding children’s behavior Parents’ role It is fundamentally the parents’ duty to guide their children towards the right path. Parents that find that their child steals should first teach the child with patience and love not to steal. Parents should tell what the consequences of stealing are and why it is considered a sin in the religion and a crime in the law. Most probably, the child would not steal again. If the child does, next time the parents should beat and scold the child for this and again forbid him/her to steal. Most children would def initely stop stealing. Still if a child steals, parents should refer the case to a psychologist or police. Teachers’ role Teachers also assume very important roles in guiding the children towards the right path. Since children remain with them for a considerable portion of the day at school, teachers get to learn the psychology of each child and can thus know

Decision Analysis Essay Example for Free

Decision Analysis Essay Finally, some typical problem classes are examined and some requirements for prototypical structures are discussed. An introduction to problem structuring Decision analysis can be divided into four steps: structuring the problem; formulating inference and preference models; eliciting probabilities and utilities; and exploring the numerical model results. Prac* This research was supported by a grant from the Department of Defense and was monitored by the Engineering Psychology Programs of the Office of Naval Research, under contract While writing this paper, the author discussed the problem of structuring extensively with Helmut Jungermann. The present version owes much to his thought. Please don’t take footnote 3 too seriously. It is part of a footnote war between Ralph Keeney and me. ** Presently with the Social Science Research Institute, University of Southern California, University Park, Los Angeles, CA 90007, (213) 741-6955. 12 D. von Winterfeldt /Structuring decision problems titioners of decision analysis generally agree that structuring is the most important and difficult step of the analysis. Yet, until recently, decision analytic research has all but ignored structuring, concentrating instead on questions of modeling and elicitation. As a result, structuring was, and to some extent still is, considered the ‘art’ part of decision analysis. This paper examines some attempts to turn this art into a science. Trees are the most common decision analytic structures. Decision trees, for example, represent the sequential aspects of a decision problem (see Raiffa 1968; Brown et al. 1974). Other examples are goal trees for the representations of values (Keeney and Raiffa 1976) and event trees for the representation f inferential problem aspects (Kelly and Barclay 1973). In fact, trees so much dominate decision analytic structures that structuring is often considered synonymous to building a tree.

Computational Chemistry for Drug Discovery

Computational Chemistry for Drug Discovery Computer Chemistry Computational chemistry is a branch of chemistry that uses computers to assist in solving chemical problems. It uses the results of theoretical chemistry, incorporated into efficient programs, to calculate the structures of molecules and solids. In theoritcal chemistry, chemists, physicist and mathematics develop algorithms and computer programs to predict atomic and molecular properties and reaction paths for chemical reactions. Computational chemists, in contrast, may simply apply existing computer programs and methodologies to specify chemical question. There are two different aspects to computational chemistry. Computational studies can be carried out in order to find a starting point for a laboratory synthesis, or to assist in understanding experimental data, such as the position and source of spectroscopic peaks. Computational studies can be used to predict the possibility of so far entirely unknown molecules or to explore reaction mechanisms that are not readily studied by experimental means. Computer-aided drug discovery/design methods have played a major role in the development of therapeutically important small molecules for over 2-3 decades [133]. Over the past couple of decades, many powerful standalone tools for computer-aided drug discovery have been developed [134]. In silico metabolism After adopting combinatorial chemistry and high throughput biological screening in the past couple of decades, the pharmaceutical industry generated a large collection of potent and selective compounds for numerous targets. However, to become an optimal drug, in addition to potency and selectivity, a compound must have appropriate ADME (absorption, distribution, metabolism and excreation), safety and developability characteristics. Relaying solely on potency in the early stage of drug discovery can result in disproportionate attrition after clinical candidate selection contributing to the exorbitant costs of discovering and developing drugs. Only about one in ten of those diligently chosen, highly potent and selective candidates that enter development reach the market often due to inadequate ADME properties. Therefore, it is extremely important to consider the ADME characteristics of compounds earlier in the discovery process to wager bets on compounds that have a greater potential t o survive the development and clinical trail stage of drug development. Increasing the odds of success to one in five (instead of ten) would reduce the total cost of bringing a new therapeutic to the market by 33%. Experimental determination of ADME and pharmacokinetic (PK) characteristics is both expensive and time consuming, and is not practical for large numbers of compounds, especially when the pharmaceutical industry is under severe pressure to cut costs and improve efficiency. The Price tag to support various ongoing discovery projects in pharmaceutical company for synthesis and high throughput measurement of permeability, solubility, metabolic stability and acute toxicity can run into millions of dollars. Therefore, much attention is being focused on the application of in silico screens to reliability predict ADME attributes solely from molecular structure. In silico prediction of ADME properties will not only reduce cost and development cycle times by wisely directing resources to essential experimental testing, but also bring forward their consideration earlier at the lead generation stage when compounds are being synthesized and tested almost exclusively to meet pharmacological target potency levels. At the cost of experimental results indicated above, a mere 10-20 % reduction in high throughput experimental measurement of permeability, solubility, metabolic stability, acute toxicity through the use of in silico screens can lead to significant savings. Further, application of in silico screens offers an ideal ‘fail-early-fail-cheaply’ strategy for drug discovery because their application requires nothing more than inputting the basic structural information of a compoun d into a validation model. Metabolic Stability Measurement in Drug Discovery At most major pharmaceutical companies, metabolic stability assays are conducted at the first investigation into the metabolism of a compound. These in vitro assays generally utilize liver microsomes and/or hepatocytes to furnish important information about the rate and/or metabolism. In vitro metabolic studies are important in optimizing pharmacokinetic properties such as in vivo half life, maximum concentration and systemic exposure, because rapid metabolism is often a key factor contributing to poor exposure. The metabolic stability data is helpful for ranking molecules with respect to their ability to resist metabolism. Though high-throughput automated metabolic stability assay systems have been developed by the major pharmaceutical companies, screening a large number of compounds is still intensive. Thus, in silico prediction of metabolic stability can be used to rationalize experimental testing and have significant resources. Further, these models allow for prediction of metabolic stability for virtual libraries, thus bringing forwarded their consideration earlier to hit-to-lead stage. In silico Models for Metabolism Studies There are several types of in silico tools available for investigations into metabolism. These include knowledge based systems (metabolism databases) rules based or expert systems and quantity structure properties relationship (QSPR) and enzyme structure modeling systems. At its simplest, the partition coefficients, Log P (or its computed equivalent), of a drug in the n-octanol-water system has been shown to loosely correlate with the metabolic stability of a compound. As in silico calculations of Log P values have become readily available, they are being implemented in many of the current metabolism prediction packages. The earliest in silico metabolism tools were the metabolic reaction databases. In principle, these are databases with the published metabolic reactions and structure of parent compounds and their metabolites. Some of these allow creation of corporate metabolic databases as well. In most cases, these databases can be searched for specific biotransformation (by structure and substructure), biotransformation keywords, and by other user-defined fileds. The key advantage of this knowledge based in silico systems is that they include detailed metabolism findings and original references. Prediction of Metabolites The above mentioned knowledge based systems provided the groundwork for the development of rules based in silico predictors of metabolites, also called expert systems. Commercial rules based programs such as METEOR, META and MetabolExpert iteratively interrogate the chemical bonds of a molecule and apply programmed biotransformation rules in a predetermined hierarchy. As one can imagine, without means of terminating the metabolism tree a very large numbers of metabolites will be generated of predicted. Several of these programs allow the user to specify the number of levels of biotransformation or may use a LogP calculation to terminate the biotransformation process. Prediction of Sites of Metabolism The mechanism of oxidation by CYPs is though to be constant across all CUPS. One of the most important steps in the oxidation of drugs (by CYPs) is the ability of the perferyl oxy species (FeO+) to carry out a one-electron oxidation through the abstraction of hydrogen atoms. In silico packages such as Admensa, COMPACT and Metasite calculate the likehood of abstracting a hydrogen atom from all sites on a molecule, and then quantify which sites are most likely to be oxidized. The greatest advantage of these types of predictions is the ability to quantify the most likely major â€Å"hot spots† on the molecule. Prediction of Substrate Binding The ability of a molecule to properly dock on the active site of enzyme plays a major role in accurately determining the site(s) of metabolism on a molecule. Therefore, modeling of the P450 active sites has long been a goal for metabolism prediction. Some of the first attempts to model the active site of metabolizing enzymes used pharmacophore, site directed mutagenesis, and protein homology. Using homology models built from bacterial and mammalian P450s, in silico studies of docking potential substrates into the active site have been performed with mixed success. Now that the crystal structure for human CYP3A4, CYP2C9, CYP2C8 and CYP2A6 are available docking experiment with these models should more reliably predict the sites of metabolism on a molecule that the predictions form the homology models. Prediction of Metabolic Inhibition One of the causes of drug-drug interactions is the inhibition of metabolic pathways. Enzyme inhibition by a drug leads to a decrease in metabolism and intrinsic clearances, and an alteration in pharmacokinetics of a co-administered drug. Any knowledge around the potential of drug-drug interactions is useful for a quantitative assessment of the ability a new molecular entity to inhibit the metabolism of another drug. In silico methods to predict drug-drug interactions are mostly limited to competitive inhibitors because they rely primarily on the binding models in the used as templates with alignment and orientation of core structure in an active site. However, the quality of prediction depends on the structural similarity to the molecules that were used to build the model. Inhibitors of CYP2D6 and CYP2C9 have been predicted using the CoMFA method. For inhibitors of CYP3A4, CYP2C9 and CYP2D6, methods such as CATALYST and GRIND have been used to reduce the bias in the alignment of inhibitors. Prediction of Enzyme Induction The induction of drug metabolizing enzymes is an additional way in which co-administered drugs can affect the clearance and pharmacokinetics of a given drug. Induction or increased expression of the drug metabolizing enzymes leads to an increase in the rate of metabolism and ultimately, to increase intrinsic clearance. Therefore, enzyme induction leads to decreased drug exposure which may results in therapeutic failure. Most often, the induction of enzymes occurs through the activation of nuclear receptors such as the Arylhydrocarbon receptor (Ahr), the Pregnane X receptor (PXR) and the constitutive Androstane Receptor (ACR). The activation of nuclear receptors PXR and CAR are responsible for the induction of several drug metabolizing enzymes including CYP3A, UGT1A1, SULT1A and CYP2C9. On the other hand, induction of CYP1A, SULT1A1 and UGT1A1 has been associated with activation of AhR. Prediction of Metabolic Stability As mentioned above, metabolic stability influences both oral bioavailability and half life of a drug. There is good correlation between in vitro metabolic stability and in vivo clearance. Therefore, the assessment of metabolic stability of compounds is being demanded and earlier in discovery projects. To meet these needs, in silico models are commonly employed. As described above, many different in silico tools focused on studying different aspects of metabolism have been developed. In our experience, the choice of the in silico tool by a user should primarily be guided by the type of information and level of accuracy that is desired. It is imperative that the developers of these in silico tools continually refine and validate them to reliably predict and quantify the metabolic fate of drug in humans. On the other hand, the chemists, biologists and ADME scientist on project teams to evaluate and use the existing in silico tools and to challenge their developers to demand tools that will rationally and efficiently move the discovery projects forward. Metabol Expert Metabol Expert is an ideal program for a quick prediction of the metabolic fate of compound in the drug discovery process during the dispositional research phase. Metabol Expert is a unique tool for initial estimation of the structural formula of metabolites. Metabol Expert is a rule based system with open architecture, in other words, the chemists, metabolism researchers, drug disposition experts and environmental managers can understand, expand, modify or optimize the data on which the metabolic structural estimation relies. Commercialized by Compudrug in 1987, Metabol Expert is composed of a database, a knowledge base and several prediction tools. The basic biotransformation database contains 179 biotransformations, 112 of which are derived from Testa and Jenner, the others are based on frequently occurring metabolic pathways. The transformation knowledge-base is composed of if-then type rules. Each is composed of our components, the structure changed during the transformation, the new substructure formed, a list of substructure at least one of which must be present in the molecule for the biotransformation form occurring. These rules have been derived from the literature by experts and are input into the system by means of graphical tools. The system is open so that new rules can be added or existing ones modified or deleted. There are two types of predictions in Metabol Expert. In the first type, the system tries to match basic transformations automatically. There is a filter so that biotransformation sequences can be arrested after generation of a specified number of metabolites. Basic transformations are classified as phase I or phase II. In the event of a phase II metabolite being generated, the sequences are arrested and the metabolite is not included in the next level. If a transformation results in the generation of two metabolites, then both are passed into the next level. The second type of analysis is an extended prediction model in which metabolites generated from basic transformations is compared to a list of transformations in a learned tree for a given species and the analogues are then listed in order of similarity. The program then attempts to quantify predictions based in the information in the learned tree. MexAlert MexAlert was developed to be an ideal assistant for high-throughput screening. It is advantageous to consider metabolism still before synthesis of the compounds, in order to exclude unwanted metabolic pathways, leading, for example, to first pass effect or to formation of toxic intermediates. MexAlert predicts first pass metabolic pathways by quickly identifying sites on the molecule where Phase II metabolic transformations (in other words, conjugation) may occur. It is rule based system; the rules are selected from among the Phase II transformations in the animal knowledge base, and modified according to in vivo experimental example of first-pass effect pathways. In silico toxicity prediction Attrition during the drug development process is a serious economic problem for the pharmaceutical industry and it is often due to inappropriate ADME/Tox characteristics. IT has been estimated that 20-40% of the drug failure in investigational drug development phases are due to safety issues, not continuing multiple incidents of adverse effects of existing drugs. The early drug discovery process needs to address in parallel not only potency but also pharmacokinetics and toxicological properties. Van de Waterbeemd and his colleagues at Pfizer have called this approach ‘property-based design’, emphasizing the importance of the critical combinations of physical and structural properties that contribute to ‘druglikeness’. Ideally this process should begin early in discovery, using computational models to screen both virtual libraries and available compound collections to identify compounds with the desired properties (good potency, ADME and low toxicity). Often molecular size and lipophilicity have an important effect on all three properties. High biological activity is frequently associated with high LogP, but this may also raise the probability of high toxicity. In the 1990s, drug companies invested heavily in combinatorial chemistry and high-throughput screening (HTS) as a source of leads for new targets. Most screen actives turned out to be large and/or hydrophobic, clearly contraindicating to the principles of minimal hydrophobicity. The most visible outcome was not even that they were toxic (because most compounds did not advance that far in development), but that they were either insoluble or non-absorbable. This overshadowed any toxicological consideration in the early stages of drug discovery, bringing forward compounds solubility and permeability as the most urgent problems to address. In the late 1990s the concepts of drug-likeness and lead likeness emerged and simple rules were formulated e.g. â€Å"rule of 5† to warn chemists when compounds were well outside the property space normal for orally active drugs. These rules are now widely used in Virtual Screening to remove undesirable compounds from consideration prior to their synthesis or acquisition. In addition to simple property filters toxicological issues should also be considered because otherwise any specific hazardous sub structural effects are ignored. Some of the harshest reactivity effects are identified and removed using predefined alert substructures (e.g., acid halides) (sometimes called â€Å"garbage filters†). The problem is the most of such alert substructures are â€Å"chameleonic† in nature, i.e., they may not necessarily cause toxic effects depending on other functional groups and overall molecular structures (e.g., acid halides). To fix this, all chameleonic† substructures (from â€Å"garbage† filters and beyond) must be supplemented with class specific QSAR’s for different health effects, yielding toxicological expert systems. Such systems can be used in virtual screening along with â€Å"drug –likeness† filters to subdivide compounds into â€Å"safe†, â€Å"hazardous† and â€Å"Questionable†. Promising compounds need further toxicological evaluation, but this cannot be done by predicative methods alone due to multiple knowledge gaps in their training sets and limited numbers of considered toxicological end points. Sometimes further evaluation is done during lead optimization, when chemical structures are covalently modified and tested. At this stage various toxicological predictions are used to prioritize both compounds that are to be tested and in vitro methods can reliably predict drug’s effect on a whole animal system, yet Animal Tests are not usually done until drug development candidates are identified. By this time drug development cost can reach substantial levels, economic risks become considerable. Thus any predictive tools that help to identify adverse effects in animals prior to conducting such testes are highly desirable. If a known toxic pharmacophore is identified and closely related to the pharmacophore required for activity at the therapeutic target then series specific SAR is needed to aid design of molecules with an adequate separation between the therapeutic dose and the dose threshold for the toxic effect. Since it is essential to have an in vitro surrogate that can model the desired in vivo effect on a significant number of compounds. Some of the more important end points for which in vitro surrogates that can model the desired in vivo effect on a significant numbers of compounds. Some of the more important end points for which in vitro surrogates have been used are: QT prolongation in heart due to blockade of the hERG potassium channel, hepatotoxicity due to compounds that produce phospholipidosis and hepatotoxicity due to induction of CYP450 enzymes. To summarize, in drug design toxicity predictions can be useful for three purpose – virtual screeing, prioritization of compounds and in vitro tests, and prediction of health effects in whole animal systems. Although many toxicologists are understandably leave us with no choice but to make the attempt using available animal toxicity database.

Effect of Changing Concentration on the Order of Reaction

Effect of Changing Concentration on the Order of Reaction Title : An Investigation into the Effect of Changing the Concentration by Continuous Method on the Order of Reaction Planning A. Hypotheses I predict that the rate of reaction is influenced by the concentration of the reactants; and that the rate of reaction and the concentration of reactants decrease as time intervals increase. I predict that the order of reaction is affected or influenced by the concentration of the reactant. I also predict that the change in concentration of reactants affects the rate of reaction proportionately and hence, the order of reaction. Such that, if the concentration of the reactants is reduced by half, the rate of reaction will also decrease by a certain proportion. The reaction that will be analyzed in this experiment is between a metal (magnesium ribbon) and an acid (sulfuric acid). The reaction is shown by the chemical equation below: Mg (s) + H2S04 (aq) → MgS04 (aq) + H2 (g) In this experiment, 0.15 grams of magnesium ribbon will be used in excess, together with 10 cubic centimeters of 0.3 M sulphuric acid (H2SO4). The continuous method will be used, where the metal is in excess and the reaction goes to completion. The volume of the hydrogen gas (H2) will be collected at a measured time interval of 30 seconds. These volume readings at the time intervals shall be recorded and analyzed. III. Background The rate of a reaction depends in part on the concentrations of the reactants. The rate at which a reactant or reactants is transformed into products is the change in concentration of the reactant or reactants with time, (Wilbraham, et.al., 1997). Mathematically, the rate can be expressed as: Rate = Change in Concentration of Reactants / Change in time The formula implies that the rate of disappearance of the reactants is proportional to its molar concentration. Hence: Change in Concentration of Reactants / Change in time = proportional to the concentration of reactants The reaction rate has to be experimentally determined. From the reaction rate equation, the order of reaction can be obtained. The order of reactions can be classified as zero order, first order, or second order, with respect to only one reactant. IV. Risk Assessment In this experiment, sulphuric acid (H2SO4), will be used as a reactant. Since it is a strong acid and is very corrosive, I will observe the following precautionary measures: Wear protective goggles for the eyes. Avoid pipetting the sulphuric acid by mouth. Avoid inhalation of sulfuric acid. Care in handling the acid should be observed. It should be prevented from being knocked over. V. Fair Test To ensure that the results that I will obtain in the experiment are reliable and accurate, I will observe the following: The volume measurements of the sulphuric acid reactant will be made very accurately by reading from the lower meniscus of the 10 cubic centimeter mark The bung will be securely and tightly placed to prevent the collected hydrogen gas (H2) from escaping. The weight measurements of the magnesium ribbon will be made very accurately. All materials will be thoroughly cleaned before each use in order to prevent contamination. The experiment will have 3 runs or replicates in order to attain a high reliability of results. VI. Procedure of the Experiment: Materials needed: Stopwatch for time interval measurements 100 cc gas syringe for the Hydrogen gas collection 100 cc conical flask for the sulphuric acid 100 ml graduated cylinder for measuring the sulphuric acid Analytical balance for measuring 0.15 grams of magnesium ribbon Procedure: 1. Set up the materials while making sure that they are thoroughly clean and dry. 2. Using a graduated cylinder, measure 10 cc of 0.3 Molar concentration of sulphuric acid. 3. Carefully weigh 0.15 grams of magnesium ribbon using an analytical balance to make sure that the weight measurement is accurate. 5. Put the 0.15 grams of magnesium ribbon into the conical flask with the sulphuric acid. 7. Measure the volume in cubic centimeters of hydrogen gas collected in the gas syringe at every time interval of 30 seconds. 8. Record the volume of collected hydrogen gas at each set time interval. 9. Make 2 more runs of this experiment by repeating steps 1-8 at every run. VII. Results. Below are the tabulated volume measurements at every time interval: Table 1: Volume Measurements for Run 1 The data in Table 1 were plotted in a graph below: Graph 1: Volume vs. Time (Run1) For Run 2, the data were obtained were tabulated below: Table 2: Volume Measurements for Run 2 The data in Table 2 were plotted in a graph below: Graph 2: Volume vs. Time (Run 2) For Run 3, the data were obtained were tabulated below: Table 3: Volume Measurements for Run 3 The data in Table 3 were plotted in a graph below: Graph 3: Volume vs. Time (Run3) All three graphs show the trend that as time increases, the volume of the reactant decreases, while the volume of the product increases. B. Calculation of the Concentration of Reactant From the reaction: Mg (s) + H2SO4 (aq) → MgSO4 (aq) + H2 (aq) Concentration is measured in terms of Molarity, where Molarity is equal to the number of moles of solute divided by liters of solution: Molarity = No. of moles of solute / Liters of solution For Magnesium (Mg), 0.15 grams were added to sulphuric acid. The number of moles is equal to: weight in grams divided by the formula weight. Hence, the number of moles = wt. in grams / FW. Since 0.15 grams were used, 0.15 grams should be divided by the formula weight of Magnesium (Mg), which is 24. So: 0.15 grams / 24 = 0.00625 moles for Mg. To get the molar concentration, the number of moles will be divided by the volume of the solution in liters, which is 0.01. So, the molarity of Mg is : 0.00625 / 0.01 = 0.625 M For the sulphuric acid (H2SO4) used, the molarity is 0.3 M. The number of moles of H2SO4 used is determined by multiplying the molar concentration by the volume of solution in liters. Hence: 0.3 moles/L X 0.01L = 0.003 moles. From the chemical equation of the reaction, for every 0.003 moles of H2SO4 used, the same amount of moles (0.003) of hydrogen gas (H2) is given off. The molar concentration of the hydrogen gas evolved can now be determined for each respective time interval, by dividing the number of moles by the volume obtained. For run 1: The concentration of the product can now be calculated, using the formula for reaction rate, where: Molarity = Number of moles / Liters of solution The data for the concentration of the hydrogen gas are tabulated below: Table 4: Molarity of the hydrogen gas (H2) The molarity values tabulated above are plotted in the graph below: Graph 4: Concentration vs. Time (Run1) Graph 5: Concentration vs. Time (Run 1) Showing the Gradient of the Tangent Curve The rate of reaction was calculated by measuring the gradient of the tangent of the curve above, as depicted by the red line. Hence, the gradient of the tangent is equal to 0.12 – 0.05 / 150 = 0.00046. From the rate equation, the rate constant (k) can be obtained by the formula: k = rate x [H2SO4]. So: k = (0.00046) / 0.3 = 0.153. The rate equation is: Rate = k [H2SO4] Rate = (0.153) (0.003) = 0. 000459 or 0.0046. Hence, this value is equal to the gradient of the tangent of the graph above. This shows that the rate is directly proportional to the concentration of the sulphuric acid (H2SO4). Table 5: Concentration of Gas Collected and Rate of Reaction (Run 1) The plotting of tabulated data above results to the graph below: Graph 6 Rate vs. Concentration (Run 1) The Rate –Concentration Graph for Run 1 above shows that the concentration of hydrogen gas (H2) is directly proportional to the rate of reaction. Thus, the concentration of sulphuric acid (H2SO4) is also directly proportional to the rate of reaction, whereby, as the concentration decreases, the rate of reaction also decreases. Since the Magnesium ribbon is in excess, only the sulfuric acid can be allowed to change. Having it in excess is to make sure that its concentration does not change. Using the rate of reaction: Rate = k [H2SO4] And applying the rate equation to the chemical equation in the reaction: Mg (s) + H2SO4 (aq) → MgSO4 (aq) + H2 (g) The rate equation is now: Rate = k [Mg] Â º [H2SO4]Â ¹. Since Mg concentration does not change in the reaction, it is the zero order. On the other hand, since H2SO4 is in the first order of reaction, the rate is directly proportional to its concentration, as measured in the experiment by the concentration of the H2 gas collected, the overall order of reaction is: 0+1 = 1. For Run 2, the table below shows its concentration. Table 6: Molarity of the Hydrogen gas (Run2) The table of Concentration and Time for run 2 gives the following graph: Graph7: Concentration vs. Time (Run 2) The Concentration –Time Graph for run 2 above shows the same trend as in run 1, where it shows an inverse proportionality: as time increases, the concentration of the sulfuric acid ( H2SO4) decreases as measured by the concentration of the hydrogen gas (H2) collected. The rate of re

Post Colonial Interpretations of Shakespeare’s The Tempest Essay exampl

Post Colonial Interpretations of Shakespeare’s The Tempest â€Å"†¦do we really expect, amidst this ruin and undoing of our life, that any is yet left a free and uncorrupted judge of great things and things which reads to eternity; and that we are not downright bribed by our desire to better ourselves?† – Longinus Since the seventeenth century many interpretations and criticisms of William Shakespeare’s The Tempest have been recorded. Yet, since the play is widely symbolical and allegorical Shakespeare’s actual intentions behind the creation of the play can never be revealed. But it is precisely this ambiguity in intention that allows for so many literary theorists, historians, and novelists to offer their insight into the structure and meaning of the play. For many years much of the critical treatment of the play has come from an educated European heritage, like the play itself. However, beginning in the nineteenth century with the re-emergence of the original text of the play and a growing global awareness in Caribbean and African nations, many attitudes were arising about the apparent cultural associations of the play’s characters and the largely heretofore unchallenged European views that had dominated popular ideology. What was once superficially taken as a play about the expansion of European culture into the Americas, was now being explored for its commentary about the inherent dominance and oppression of the natives of the Barbadian islands (the geographical setting of the play), and further as a commentary on slavery and oppression as a whole. The plays main characters, Prospero and Caliban, have come to personify the thrust of the oppressors vs. oppressed debate. In the introduction to Critical Essays on Shakesp... ...d Alden T. Vaughan. New York: G.K. Hall & Co, 1998. 247-266. [1] Accounts of the Caribbean islands from the misdirected crew of the Sea Venture – a colonial ship – who in a 1609 storm landed off the Bermudas and took shelter there for the winter. [2] See p. 8 of Jonathan Goldberg’s essay, The Generation of Caliban. [3] See p. 15 of Jonathan Goldberg’s essay, The Generation of Caliban. [4] See El Triunfo de Caliban, 1898. [5] See Ariel, 1900 [6] Alden T. Vaughan’s essay on Caliban in the â€Å"Third World†: Shakespeare’s Savage as Sociopolitical Symbol cites Rodo and Dario’s European-American association with Caliban as Monstrous (249) [7] This perspective references the Longinus quotation at the head of this essay, suggesting that perhaps critics have alterior motives for their theories rather than simply what they outwardly offer as their rationale.

Starbucks Coffee :: Starbucks Coffee Case Study

Starbucks Coffee Table of Contents Introduction 3 Product Analysis 3 Product Overview 3 Market Structure 4 Competition 5 Dunkin Donuts 7 Krispy Kreme 3 McDonalds 8 Panera Bread 8 Elasticity Estimates Pricing Strategy 10 Forecast 12 Determants of Demand 13 Forecast Model 15 Forecast Summary 15 Works Cited Introduction With the economy in trouble, the stock market tanking it is important to start your day with a good cup of coffee to take on these challenges. Can Starbuck’s sustain it business model and place in the market? The paper examines Starbucks business and it respective practices. In 1971, the original Starbucks opened in Pike Place Market in Seattle, Washington by three partners named Jerry Baldwin, Zev Siegal, and Gordon Bowker. Their focus was to sell coffee beans and equipment. They purchased green coffee beans from Peet’s, a specialty coffee roaster and retailer, during their first year of operation. Later, they began buying coffee beans directly from the growers. In 1983, an entrepreneur by the name of Howard Schultz joined the company; Schultz felt that the company should sell coffee and espresso drinks as well as coffee beans. The partners felt that selling coffee and espresso drinks would take away from their primary focus of selling coffee beans. Since the idea did not work, Schultz started his own company called II Giornale coffee bar chain in 1985. In 1987, the original owners of Starbucks sold their chain to Schultz’s II Giornale. Schultz changed II Giornale outlets to Starbucks chains and quickly began to expand. Starbucks coffee has grown into the largest coffeehouse company in the world with 16,120 stores in 94 countries such as in Australia, Canada, China, Puerto Rico, etc. Starbucks has thirty blends and single origin coffee. Starbucks brand coffee can also be purchased in local stores to brew at home. Starbucks employs over 140,000 employees worldwide with over five million customers a week. At one point they had typical customers coming in on an average of six times a month while loyal customers come in on an average of eighteen times a month spending averaging $50. Starbucks is one of Fortune magazine’s 100 Best Companies to work for in 2008 and is Business Ethics 100 Best Corporate Citizens for the fourth year. Product Analysis Product Overview Starbucks product line has grown to include fresh brewed coffee, hot and iced espresso beverages, coffee and non coffee blended beverages, Tazo tea, baked pastries, sandwiches, and salads. Starbucks paraphernalia includes coffee grinders, espresso machines, coffee brewers, music CD’s, books, movies and gift cards.

Cell Bio Lab Report Essay

The purpose of this lab was to test the biological activity of ConA by performing a hemagglutination assay. If ConA is active then agglutination will occur due to ConA’s free receptors being able to bind to the glucose residues on the sheep’s red blood cells. If ConA is not active then no agglutination will occur. To test the hemagglutination reaction, two types of ConA solutions were compared, a purchased control ConA solution in buffer as the positive control, and a purified solution of ConA in buffer previously purified in lab. Each solution was at a 2mg/ml concentration of ConA in ConA buffer, which is necessary for ConA’s biological activity. Two variables were added, Galactose and Mannose, to the ConA solution to compare the effects each had on the hemagglutination reaction. I hypothesize for ConA to be able to agglutinate the red blood cells if in the adequate concentration and if in the presence of Galactose, not Mannose. Mannose will inhibit the ConA fro m binding to the red blood cell’s membrane, preventing agglutination. RESULTS The reaction plate containing the ConA dilutions was incubated over the weekend and resulted in all wells being pink, appearing as if every well had agglutinated. There was a vague outline of the non-agglutinated cells in various wells. The last agglutination was observed at titer 0.0625 (1/16). Agglutination was seen in rows A, B D, and E (row A contained the control ConA, row B contained the control ConA + Galactose, row D contained the sample ConA, and row E contained the sample ConA + Galactose). In the well rows C and F which contained control ConA + Mannose and sample ConA + Mannose, agglutination did not occur at any concentration of ConA. Row G, the negative control appeared to have agglutinated as well as Row H, which contained only ConA buffer. DISCUSSION AND CONCLUSION The results did not support my hypothesis for the biological activity of ConA. There are some sources of error that could explain the results obtained. It’s possible there was a problem with either the ConA buffer or the sheep red blood cells to allow for all wells to turn pink and appear agglutinated. Another explanation of the irregular results was there might have been cross contamination from not changing tips when transferring to different ConA concentrations, or if bubbles were introduced while diluting the ConA, making the results difficult to interpret. For wells A, B D, and E as ConA became more diluted or decreased in concentration, it became more difficult for it to effectively crosslink and agglutinate the red blood cells. Well D, the positive control that contained the purchased ConA resulted in agglutination of the first couple wells, then no agglutination as the ConA concentration decreased, similar to Row A. Wells B and E that had the Galacatose additive obtained the same titer of the control ConA because ConA does not bind Galactose. Galactose doesn’t interfere with ConA from binding to the sugar residues on the red blood cells. Mannose on the other hand, is an inhibitor to ConA’s binding sites. The Mannose in solution competed with the ConA and did not allow to bind to the sugar residues on the red blood cells as seen in rows C and F. Row G, the negative control, should have resulted in non-agglutination, similar to the rows containing the Mannose additive. The results observed showed agglutination formed in this row. Lastly, Row H should have shown non-agglutination through out because the well contained only ConA buffer, not ConA protein. In conclusion, the results did not clearly explain the biological activity of ConA with the hemagglutination assay. The experiment contained too many anomalies to get a clear determination of ConA’s functionality post purification. The results did show that a change in the concentration of ConA would alter the strength of the reaction. Also, ConA’s ability to bind to sugar residues can be affected if ConA has to compete or is inhibited to bind to a cells membrane. LITERATURE CITED Cell Biology 3822 Lab Manual, Cell Surface Glycoprotein Receptor Analysis Using Concanavalin A Lab 7. Pearson Learning Solutions. 2012: 147-154. Madeleine Zaechringer. Cell Biology 3822 Analysis of purified ConA via Hemagglutinatino Assay Lab 7: Powerpoint. 2014.

Bristol Myers Squibb

Bristol Myers Squibb was formed in 1887 when McLaren Bristol and John Ripley Myers bought the Clinton pharmaceutical Company in Clinton New York. In 1900 Bristol-Myers broke through into the black — it has remained there ever since. In 1924, gross profits topped $1 million for the first time in Bristol-Myers’ history. The company’s products were then sold in 26 countries. At this point, the shares held by John Myers’s heirs became available for sale, triggering a series of moves that in 1929 turned Bristol-Myers into a publicly held company, listed on the New York Stock Exchange.The postwar depression prompted Bristol-Myers to jettison its pharmaceutical business and devote itself entirely to its specialties: Sal Hepatica and Ipana, its two big winners, and a dozen or so assorted toiletries, antiseptics and cough syrups. By the end of the war, it was clear that penicillin and other antibiotics represented an immense opportunity for Bristol-Myers. In 1921 t he Squibb Company coined its slogan: â€Å"The priceless ingredient in every product is the honor and integrity of its maker†, which is now the corporate slogan of Bristol Myers Squibb.In 1989 Bristol-Myers merged with Squibb, creating a global leader in the health care industry. The merger created what was then the world’s second-largest pharmaceutical enterprise. BMS is now ranked #8 in the pharma sector. Current Drugs, Issues and Interests The Company operates in three segments: Pharmaceuticals, Nutritionals and Other Healthcare. The Pharmaceuticals segment is made up of the global pharmaceutical and international consumer medicines business. The Nutritionals segment consists of Mead Johnson Nutritionals (Mead Johnson), primarily an infant formula and children's nutritional business.The Other Healthcare segment consists of ConvaTec, Medical Imaging and Consumer Medicines (United States and Canada) businesses. In 1991, the company received U. S. Food and Drug Adminis tration (FDA) approval in the U. S. for Videx ® (didanosine) also known as ddI, making it the second medicine available for treating HIV infection (the other being AZT). Other approvals that year included an antibiotic, Cefzil ® (cefprozil); two cardiovascular agents, Pravachol ® (pravastatin sodium) Tablets and Monopril ® (fosinopril sodium) Tablets; and a central nervous system drug, Stadol NS ® (butorphanol tartrate) C-IV.In that same year, the companies signed a Cooperative Research and Development Agreement with the National Cancer Institute to research and develop a new compound for treating certain types of cancer. This compound, TAXOL ® (paclitaxel) Injection, immediately was established as the company’s top research priority. Bristol-Myers Squibb invested hundreds of millions of dollars to supply TAXOL in sufficient quantities for clinical trials, to prepare data for regulatory submission and to develop alternative sources of TAXOL (which originally was d erived from the bark of an endangered tree, the Pacific Yew).TAXOL launched in 1993 and quickly became one of the world’s most widely used cancer treatments. For a few years BMS held the exclusive rights to harvest the bark of the endangered yew trees on US soil, the tree’s bark is used in making TAXOL. By the end of 1995, the company had over 60 product lines with $50 million or more in annual sales worldwide. At the beginning of 1998, the FDA granted clearance to market Excedrin ® Migraine for the relief of migraine headache pain and associated symptoms. Excedrin Migraine became the first migraine headache medication available to consumers without a prescription.In 1999, Bristol-Myers Squibb announced SECURE THE FUTUREâ„ ¢, a $100 million commitment to advance HIV/AIDS research and community outreach programs in five southern African countries: South Africa, Botswana, Namibia, Lesotho and Swaziland. And in 2000, Bristol-Myers Squibb, together with four other pha rmaceutical companies and international agencies, joined the UNAIDS Drug ACCESS Initiative. The ACCESS program aims to make antiretroviral medicines and therapies to treat opportunistic infections more widely available in African countries that have developed a coherent national AIDS strategy.As part of the program, the company offered to lower the prices of HIV/AIDS medicines in those countries by 90 percent. More recently, Bristol-Myers Squibb took its access efforts a step further, offering HIV/AIDS drugs below cost in Africa and committing an additional $15 million for extending SECURE THE FUTURE to four Western African countries — Burkina Faso, Cote d’Ivoire, Mali and Senegal. The company is also ensuring that its patents do not prevent inexpensive HIV/AIDS therapy in Africa.The patent for Zerit, rights to which are owned by Yale University and Bristol-Myers Squibb, is now available at no cost to treat AIDS in southern Africa. However, issues like losing patents l ike this and a few more in South Africa has caused many problems for drug companies and BMS is not immune to them. In September 2000, Bristol-Myers Squibb announced a new strategy that includes a sharpened focus on medicines and an aggressive external development program. As part of this new strategy, the company announced its intention to divest its Clairol and Zimmer businesses.The company announced in June 2001 that it had entered into a definitive agreement to acquire the DuPont Pharmaceuticals Company for $7. 8 billion; an acquisition intended to further strengthen Bristol-Myers Squibb’s medicines business. With the DuPont acquisition, Bristol-Myers Squibb added Sustiva ® (efavirenz) Capsules to its HIV portfolio and also gained products such as Coumadin ® (warfarin sodium tablets, USP) Crystalline, the U. S. leading prescribed anti-coagulant and Cardiolite ® (Kit for the preparation of Technetium Tc99m Sestamibi for Injection), a medical imaging agent.In November 2002, the FDA approved Abilify ® (aripiprazole) for the treatment of schizophrenia. In 2003, the company teamed up with cancer survivor and Tour de France champion Lance Armstrong to sponsor the Bristol-Myers Squibb TOUR OF HOPEâ„ ¢, an unprecedented week-long coast-to-coast cycling event. En route, the 26-member team of cancer survivors, caregivers, physicians, nurses and researchers raised awareness of cancer research and the importance of clinical trials in developing new treatments.Reyataz ® (atazanavir sulfate), the first protease inhibitor for the treatment of HIV/AIDS with once-a-day dosing, was introduced in the U. S. in July 2003 and approved for marketing in Europe in March 2004. On March 29, 2005, the FDA approved Baraclude ® (entecavir). Baraclude, discovered by Bristol-Myers Squibb scientists, is indicated for the treatment of chronic hepatitis B infection. Bristol-Myers Squibb announced the FDA approval of Orencia ® (abatacept) for the treatment of rheumatoi d arthritis on December 23, 2005. Orencia is the first in a new class of medications for this disease.On February 28, 2006, Bristol-Myers Squibb and Somerset Pharmaceuticals announced FDA approval of EMSAM ® (selegiline trasdermal system), the first transdermal patch for the treatment of major depressive disorder. SPRYCEL ® (dasatinib), discovered by Bristol-Myers Squibb scientists, was approved by the FDA on June 28, 2006, for the treatment of chronic myeloid leukemia. Bristol-Myers Squibb and Gilead Sciences announced the FDA approval of ATRIPLAâ„ ¢ (efavirenz 600 mg/ emtricitabine 200 mg/ tenofovir disoproxil fumarate 300 mg) on July 12, 2006. ATRIPLA is the first-ever once-daily single tablet regimen for HIV.As a strategy they are focusing on ten diseases, these are affective (psychiatric) disorders, Alzheimer’s/dementia, atherosclerosis/thrombosis, diabetes, hepatitis, HIV/AIDS, obesity, oncology, rheumatoid arthritis and related diseases, and solid organ transpla nt. Current Financials The current financial information of the company from MSN Central is as below. The revenues have not been growing in spite of all the successful products that have been launched and that is an area for change. The company needs to improve its revenues and have a positive trend in profits too.The profits are almost 16%, however, that looks pale when compared to GSK and Merck – both in the 20- 22% range (Fortune 500 list). In fact at 15%, the company is ranked 10 out of 12 in the pharma sector and the revenues are 8 out of 12. That for a company that is going to be 120 years in 2007 is poor. As discussed in the current drugs, issues and interests section, the company is focusing on some key diseases and getting some fantastic drugs in the market. However, all this is somehow not improving the revenue. In fact in the last 5 years, revenue has grown at less than 2% year on year.On the current price ($24), the share gives a 6% return on investment (EPS is $1 . 43). Currently, they are benefiting from the effects of letting go of their CEO Peter Dolan and the company is touted as a takeover target. Their major problem is the failure to prevent Apotex from manufacturing Plavix. Although BMS tried to stop Apotex by getting into a deal that would give Apotex $40 million for not manufacturing the drug, the US State Attorney Generals however didn’t let the deal go through and instead the company got into an investigation because of the whole mess that the deal created.From the BMS perspective, they were doing the right thing; Plavix generates revenues of $5. 9 Billion. $3. 8 Billion are BMS and the rest is Sanofi-Aventis. $3. 8Billion is almost 20% of BMS’s revenue and Plavix gives approximately 40% of the profits in their US business. All this has a big impact on the dividend given by the company and most analysts have suggested that the dividend payout will have to be cut by almost 30-40 cents; it was $1. 12 the previous year. BMS has a good line up of drugs that are in the pipeline and would be a good takeover for any pharma company that has strong cash flow but weak pipeline. These are rumors but looking at the current scenario, it is a good possibility. The interim CEO James Cornelius headed Guidant and helped its sell-off. Vision, Mission and Goals The current vision mission and goals of BMS are referred as a pledge. The pledges are to different stakeholders and are as follows: The BMS Pledge Our company’s mission is to extend and enhance human life by providing the highest-quality pharmaceutical and related health care products.We pledge — to our patients and customers, to our employees and partners, to our shareholders and neighbors, and to the world we serve — to act on our belief that the priceless ingredient of every product is the honor and integrity of its maker. To Customers We pledge excellence in everything we make and market, providing the safest, most effective and hig hest-quality medicines and health care products. We promise to continually improve our products through innovation, diligent research and development, and an unyielding commitment to be the very best. To ShareholdersWe pledge our dedication to responsibly increasing the shareholder value of your company based upon continued growth, strong finances, productive collaborations and innovation in research and development. To Communities We pledge conscientious citizenship, a helping hand for worthwhile causes and constructive action that supports a clean and healthy environment. We pledge Bristol-Myers Squibb to the highest standard of moral and ethical behavior and to policies and practices that fully embody the responsibility, integrity and decency required of free enterprise if it is to merit and maintain the confidence of our society.The new era for BMS must ensure that the pledge to the shareholders is held more firmly than it has been in the last few years. The company must improve revenues and margins. The stagnant revenues and profits are a cause for worry in the longer run. All pharma companies are fighting against smaller companies that want to make generics and Pfizer itself has been fighting for the patent of Lipitor, the world’s best selling drug with $12. 9 Billion in revenues. BMS needs to ensure that the scandals that have been hitting it in the last 5 years never happen again and the company needs to have a higher standard of governance.Shareholder value erodes very quickly for many reasons, but off the last 3-5 years, corporate governance has been a major issue. Companies with tens of billions of dollars of revenue have disappeared and stockholders have suddenly seen their investment disappear with them. BMS has serious corporate governance issues. The company was hit by financial scandals when it was caught pushing inventories and showing them as sales. They have a court appointed overseer because of showing higher revenues and now with th e Plavix issue they are in an even bigger mess as far as corporate governance goes.Apart from that, according to IMS health, a pharmaceutical information and consulting company, sales of prescription medicines worldwide rose 7% to $602 billion,. The United States still accounts for the lion's share of that, with $252 billion in annual sales, but sales in it and the other nine biggest markets grew by only 5. 7%. But emerging markets such as China, Russia, South Korea and Mexico outpaced those markets, growing a whopping 81%. However, when we look at the overall picture 10 -20 years from now we see that the population of the developed world is going to fall and there will be more and more people who will be retired.This also means there will be more medicines required. I do not see myself dying at the age of 70 in the year 2040; medical technology will be so advanced in the next 30 years that it will probably keep me alive till I reach 80 or 90. This is great news for the pharma compa nies. However, the question beckons that the people who can afford expensive medicines for diseases that BMS is targeting are only in the developed countries where the growth has stagnated or is less than 10%. The growth is in the developing world, but the diseases that BMS is targeting are all that need lots of medicines and very expensive medicines.Taxol for example, is used for cancer patients. The medicine is now made by other companies too, and yet the prices for Taxol in the developing world are really high and people find it hard to afford Taxol. In my opinion, BMS has to handle 2 issues: First is Corporate Governance and the second is to crack the developing markets and increase market share in those countries, this will automatically increase its stagnant revenues and breathe some life into its ailing business. The markets are stagnant in the developed world.New Vision Statement I am making a few changes to the current pledges that BMS has to customers and shareholders. The changes reflect what the company needs to do in order to transform itself. To Customers We pledge excellence in everything we make and market, providing the safest, most effective, and cost effective and highest-quality medicines and health care products. We promise to continually improve our products through innovation, diligent research and development, and an unyielding commitment to be the very best. To ShareholdersWe pledge our dedication to responsibly increasing the shareholder value of your company based upon continued growth, strong finances, productive collaborations and innovation in research and development. We pledge to be extremely careful in all governance issues and not succumb to the pressures of the market. We pledge to conduct our business with utmost fairness. Key Change Issues Lack of Corporate Governance is something that no company will admit, but that is the major problem facing BMS right now. Having an overseer is a bad indicator. The key change issues that we will face while changing the attitude towards corporate governance are:1. The first issue is to change the behavior of bosses who force employees to act in ways that will be against any corporate governance policy. 2. The second change will be to create an atmosphere where an employee can raise an integrity or corporate governance concern. This is critical right now as it seems that over the last few years many things were not raised. 3. The third change will be in terms of managing the markets and expectations of all stakeholders, ultimately it is the expectations of the markets or other stakeholders that push the employees to cover up things or show a bright picture when there is none.It is important to manage the expectations. The next key change after corporate governance is to ensure that we can capture the growing markets. To capture the new markets, we will have to make a couple of changes in the way we do business. These changes are likely to be as follows: 1. Lower the cost of drugs – most of the money goes into research. The drugs that conquer markets cost hundreds of millions of dollars to make. So the cost of developing drugs has to be lowered, once this cost is lowered, the cost of the drug per se can also be lowered accordingly.2. Come with products that cater to the growing segments there – it is likely that the people in the developing countries will be using medicines that are generic. For a branded product to conquer that market, the companies have to give an added value to their product. This might mean, reworking some of the old compounds and coming up with ‘extra strong versions’ or other versions that would differentiate the medicines BMS could come up with a line of medication aimed at women with PMS or aimed at people over 70.This might be the normal medicines, but with a different potency or properties so that they would be ‘better suited’ to a different age group. 3. Newer gene types  œ this might mean that there will be opportunities as people from different races might have different problems or might need different treatments. It is possible that the genes or body types in different races might respond differently to different molecules and thus would require modifications to the current molecules. Depending on the cost of doing this modification, BMS can decide to modify certain molecules to better suit different races.How will these areas be changed? What are the broad sets of proposals for change? The Critical Change requirement is Corporate Governance. Corporate Governance is something that every company talks and boasts about but as we can see in case of BMS, this has failed grossly. The company actively needs to change the situation within its departments and especially in the higher ranks to improve the Corporate Governance scenario and educate people about the problems that are caused because of bad governance.Before I dwell into how to combat corporat e governance, I would like to talk about why officials higher up in the ranks and even some in the lower ranks resort to concealing information that might be damaging to the company. The first reason is to ensure that their jobs are secure. If a person conceals information it is because they feel that the particular piece of information will be damaging to their job, their department or their interest. This is the basic level and it is very individualistic. However, it is this same thing that drives even the bigger corporate information scandals.The second reason for concealing information or reporting wrong figures is to ensure that the company meets its goals. To take an example from an IT company, it is one thing to not report a data theft because it might compromise the jobs of the IT security personnel, but quite another not to report the bugs that might exist in the new software that a company is making. Different projects have different timelines and it is critical for compan ies to meet those timelines as revenues and profits are based on the sales of that new product.If we take windows Vista for example, vista has been delayed numerous times and because of that many partners of Microsoft are suffering, especially Intel. Microsoft has in public announced about the delays; however a smaller company might choose to not mention a delay in their quarterly update. For the officials in the company it is something that protects the shareholders and other partners from the value perspective, but what they fail to see is the long term damage that their actions are causing.Concealing information today will have its repercussions in the next two quarters and eventually if someone finds out the true picture, the stock market will kill the script and the valuation will suffer enormously. However, a public announcement about the delay will cause temporary drop in the stock valuation (till the product is back on track or launched in the market) but on a personal level , it will affect the persons’ bonus (for sure) and the growth prospects of the higher ranks who were responsible for not delivering the results.The cost of revealing the truth means jobs and immediate losses in the stock markets. Many of the higher ranking officials have stock options and this makes it even more lucrative from a personal perspective to ensure that the company is shown in good light and seen as an entity that meets its goals and beats the market predictions. The corporate governance scenario gets worse because of the stock options but it can be much better if every one looked at the picture from a long term perspective. In the longer term, the company will deliver the products and make the profits.What every individual must realize is that a company will survive beyond every employee and every leader. One employee or a leader cannot make the company, there is always a team. However, a leader can easily break the company and corporate governance is one way of d oing it with much ease. Coming to ways on how BMS can change the corporate governance culture within the organization; I would recommend the following 3 changes: 1. Top down pressure to conceal information 2. Protective climate for whistle blowers 3. Managing the expectations of the stock market and other stakeholdersTop down pressure to conceal information Driving the first one seems to be the toughest one, but this is where the board members have to set the rules and deal facts with an iron hand. All directors and Country Heads must be responsible towards Corporate Governance and the Finance people especially should run their reports through the board. The board must appoint an independent third party evaluator and auditor to ensure that the reports being presented are correct and any discrepancy must be dealt by terminating the country head and seizing all stock options that the person may have.Termination with seizure of stock options at all levels will mean that the lure of a h igh stock price will not be a motivating factor in concealing information and we can expect people to take a long term view of the situation instead of a short term view based on when their stock options might be due. With a personal lure of money gone, the top management would be forced to look at share value in the longer term and hence won’t be pushing their direct reports to fudge information.In addition to this, I recommend that one board member be assigned the task of being an auditor and also the point of contact for all kind of tip-offs or corporate governance whistle blowers. This will give the employees all over the company more faith in the system. The biggest problem for whistle blowers or people who have issues with corporate governance is that they fear for their jobs and they fear that if they still have their jobs, they will be treated will disgust in the office for going against what might be termed as ‘normal practice’ in that division.The prese nce of a board member as a person who can look into corporate governance issues ensures that people can raise concerns in confidence without the fear or being outcastes at their jobs. This board member of course needs to have a team of people who will investigate the issues that are raised. At the middle management level or at the level where people head departments at country levels, the country head must tighten the leash and implement all corporate policies.The country heads must have audits from outside parties to ensure the authenticity of the financial statements and the systems within the company. At the lower management levels the managers should be responsible for their business. However; the ultimate responsibility would be with the middle management. The board member however, should be contactable by everyone within the organization. The organization change needed is to re-align the salary packages of the people who have stock options.This would entail the compensation an d benefits team to look at the packages again and set up a new corporate policy about rewarding and retaining employees. The major change is only for the upper management to ensure that they don’t abuse their power to increase the value of their shares. The stock option change will also weed out the people who do not have a longing for working with BMS. It is very important for a company to ensure that their top management is a group of people who take the company close to their heart, and of course these people are there for the long term.Protective climate for whistle blowers The next issue we need to cover is about protecting the whistle blowers. The appointment of a board member to look after the corporate governance issues should quell any fears that a person might have about corporate governance. In addition to this, a very small step that might go a long way is to bring up issues with a pseudo identity, where people can write in and give information without being oblig ated to divulge their identity even to the board member.The whistle blowers biggest fear is that their job and career gets jeopardized if it is found out that they were the ones who raised concerns that brought down the whole unit and the jobs of several people. People take it against them and they are outcaste. I also recommend that these people have help from outside sources such as counseling etc that may be needed as they grapple with the effects of being whistle blowers or as they continue to live without talking to anyone about being the whistle blowers.In addition to this, the company should actually owe these people an incentive for doing the company a favor by helping it exposing thing internally and managing the fall out and taking corrective actions. Such revelations by outsiders can be far more damaging and bring the company into disrepute apart from all the lawsuits and the hassles of the law. The board is always responsible for ensuring that things are going on smoothl y within the company and ultimate beneficiary of having an internal system that exposes the corporate governance problems within the company actually helps the board save the company and their own reputations.